Publications 2019

1             Comparison of intradermal injection and epicutaneous laser microporation for antitumor vaccine delivery in a human skin explant model. Duinkerken, S., Lübbers, J., Stolk, DA., Vree, J., Ambrosini, M., Kalay, H. & van Kooyk, Y.  Biorxiv, 5 Dec 2019        

2             Development of a Retinal-Based Probe for the Profiling of Retinaldehyde Dehydrogenases in Cancer Cells. Koenders STA, Wijaya LS, Erkelens MN, Bakker AT, van der Noord VE, van Rooden EJ, Burggraaff L, Putter PC, Botter E, Wals K, van den Elst H, den Dulk H, Florea BI, van de Water B, van Westen GJP, Mebius RE, Overkleeft HS, Le Dévédec SE, van der Stelt M. IACS Cent Sci. 2019 Dec 26;5(12):1965-1974. doi: 10.1021/acscentsci.9b01022.       

3             Non-linearity in commercially available lipase assays: still gaps to close. Oyaert M, Delanghe J, Van den Bossche J, Ghys T, Stove V.  Clin Chem Lab Med. 2019 Dec 18;58(1):e21-e23. doi: 10.1515/cclm-2019-0587.       

4             The core fucose on an IgG antibody is an endogenous ligand of Dectin-1 Manabe, Y., Mar-chetti, R., Takakura, Y., Nagasaki, M., Nihei, W., Takebe, T., Tanaka, K., Kabayama, K., Chiodo, F., Hanashima, S., Kamada, Y., Miyoshi, E., Dulal, H. P., Yamaguchi, Y., Adachi, Y., Ohno, N., Tanaka, H., Silipo, A., Fukase, K. & Molinaro, A., 16 Dec 2019, In: Angewandte Chemie International Edition in English. Dec 2019; 58, 51, p. 18697-18702 6 p.      

5             Regulation of microglial TMEM119 and P2RY12 immunoreactivity in multiple sclerosis white and grey matter lesions is dependent on their inflammatory environment.van Wageningen TA, Vlaar E, Kooij G, Jongenelen CAM, Geurts JJG, van Dam. AM. Acta Neuropathol Commun. 2019 Dec 11;7(1):206. doi: 10.1186/s40478-019-0850-z.              

6             Biology of soft tissue repair: gingival epithelium in wound healing and attachment to the tooth and abutment surface. Gibbs, S., Roffel, S., Meyer, M. & Gasser, A.  European cells & materials. Dec 2019, 38, p. 63-78 16 p.    

7             Stroke progression and clinical outcome in ischemic stroke patients with a history of migraine. Mulder, I. A., Holswilder, G., van Walderveen, M. A. A., van der Schaaf, I. C., Bennink, E., Horsch, A. D., Kappelle, L. J., Velthuis, B. K., Dankbaar, J. W., Terwindt, G. M., Schonewille, W. J., Visser, M. C., Ferrari, M. D., Algra, A., Wermer, M. J. H. & DUST investigators.  Int J Stroke. 2019 Dec;14(9):946-955. doi: 10.1177/1747493019851288

8             Subcutaneous immunotherapy using modified Phl p5a-derived peptides hly alleviates aller-gic asthma in mice. Hesse L, Feenstra R, Ambrosini M, de Jager WA, Petersen A, Vietor H, Unger WWJ, van Kooyk Y, Nawijn MC. Allergy. 2019 Dec;74(12):2495-2498. doi: 10.1111/all.13918.     

9             Chemically engineered glycan-modified cancer vaccines to mobilize skin dendritic cells.Duinkerken S, Li RE, van Haften FJ, de Gruijl TD, Chiodo F, Schetters STT,van Kooyk Y. Curr Opin Chem Biol. 2019 Dec;53:167-172. doi: 10.1016/j.cbpa.2019.10.001.    

10           Tumor microbiome: Pancreatic cancer and duodenal fluids contain multitudes, ...but do they contradict themselves? Meijer, L. L., Zwart, E. S., Brandt, B. W., Mebius, R., Deng, D., Giovannetti, E., Zaura, E. & Kazemier, G.  Crit Rev Oncol Hematol. 2019 Dec;144:102824. doi: 10.1016/j.critrevonc.2019.102824

11           Specialized pro-resolving lipid mediators are differentially altered in peripheral blood of patients with multiple sclerosis and attenuate monocyte and blood-brain barrier dysfunc-tion. G, Derada Troletti C, Leuti A, Norris PC, Riley I, Albanese M, RuggieriS, Kooij Libreros S, van der Pol SMA, van Het Hof B, Schell Y, Guerrera G, Buttari F, Mercuri NB, Centonze D, Gasperini C, Battistini L, de Vries HE, Serhan CN, Chiurchiù V.  Haematologica. 2019 Nov 28. pii: haematol.2019.219519. doi: 10.3324/haematol.2019.219519.  

12           Activated neutrophils exert myeloid-derived suppressor cell activity damaging T cells be-yond repair. Aarts CEM, Hiemstra IH, Béguin EP, Hoogendijk AJ, Bouchmal S, van Houdt M,Tool ATJ, Mul E, Jansen MH, Janssen H, van Alphen FPJ, de Boer JP, Zuur CL, Meijer AB, van den Berg TK, Kuijpers TW.  Blood Adv. 2019 Nov 26;3(22):3562-3574. doi: 10.1182/bloodadvances.2019031609.         

13           Gain-of-function CEBPE mutation causes noncanonical autoinflammatory inflammasomopa-thy. Göös H, Fogarty CL, Sahu B, Plagnol V, Rajamäki K, Nurmi K, Liu X, Einarsdottir E, Jouppila A, Pettersson T, Vihinen H, Krjutskov K, Saavalainen P, Järvinen A, Muurinen M, Greco D, Scala G, Curtis J, Nordström D, Flaumenhaft R,Vaarala O, Kovanen PE, Keskitalo S, Ranki A, Kere J, Lehto M, Notarangelo LD, Nejentsev S, Eklund KK, Varjosalo M, Taipale J, Seppänen MRJ. J Allergy Clin Immunol. 2019 Nov;144(5):1364-1376. doi: 10.1016/j.jaci.2019.06.003.         

14           The Plasticity of the Carbohydrate Recognition Domain Dictates the Exquisite Mechanism of Binding of Human Macrophage Galactose-Type Lectin. Diniz A, Coelho H, Dias JS, van Vliet SJ, Jiménez-Barbero J, Corzana F, Cabrita EJ, Marcelo F. Chemistry. 2019 Nov 4;25(61):13945-13955. doi: 10.1002/chem.201902780.             

15           The Role of Endothelial Cells and TNF-Receptor Superfamily Members in Lymphoid Organo-genesis and Function During Health and Inflammation. Jeucken, K. C. M., Koning, J. J., Mebius, R. E. & Tas, S. W. Front Immunol. 2019 Nov 20;10:2700. doi: 10.3389/fimmu.2019.02700. eCollection 2019.          

16           Salt increases monocyte CCR2 expression and inflammatory responses in humans. Wenstedt, E. F., Verberk, S. G., Kroon, J., Neele, A. E., Baardman, J., Claessen, N., Pasaoglu, O. T., Rademaker, E., Schrooten, E. M., Wouda, R. D., de Winther, M. P., Aten, J., Vogt, L. & Van den Bossche, J. JCI Insight. 2019 Nov 1;4(21). pii: 130508. doi: 10.1172/jci.insight.130508.       

17           Profiling the unique protective properties of intracranial arterial endothelial cells. Hermkens DMA, Stam OCG, de Wit NM, Fontijn RD, Jongejan A, Moerland PD, Mackaaij C, Waas ISE, Daemen MJAP, de Vries HE. Acta Neuropathol Commun. 2019 Oct 14;7(1):151. doi: 10.1186/s40478-019-0805-4.         

18           Bacterial inclusion bodies function as vehicles for dendritic cell-mediated T cell responses. Schetters STT, Jong WSP, Kruijssen LJW, Saparoea HBVDBV, Engels S, Unger WWJ, Houben D, den Haan JMM, Luirink J, Kooyk YV. Cell Mol Immunol. 2019 Oct 8. doi: 10.1038/s41423-019-0298-x.              

19           Tissue-specific expression of IgG receptors by human macrophages ex vivo. Bruggeman, C. W., Houtzager, J., Dierdorp, B., Kers, J., Pals, S. T., Lutter, R., van Gulik, T., den Haan, J. M. M., van den Berg, T. K., van Bruggen, R. & Kuijpers, T. W. PLoS One. 2019 Oct 15;14(10):e0223264. doi: 10.1371/journal.pone.0223264. eCollection 2019.              

20           Setmelanotide, a Novel, Selective Melanocortin Receptor-4 Agonist Exerts Anti-inflammatory Actions in Astrocytes and Promotes an Anti-inflammatory Macrophage Pheno-type. Kamermans A, Verhoeven T, van Het Hof B, Koning JJ, Borghuis L, Witte M, van Horssen J, de Vries HE, Rijnsburger M. Front Immunol. 2019 Oct. 4;10:2312. doi: 10.3389/fimmu.2019.02312. eCollection 2019.

21           Targeting histone deacetylases in myeloid cells inhibits their maturation and inflammatory function with limited effects on atherosclerosis Luque-Martin, R., Van Den Bossche, J., Furze, R. C., Neele, A. E., Van Der Velden, S., Gijbels, M. J. J., Van Roomen, C. P. P. A., Bernard, S. G., De Jonge, W. J., Rioja, I., Prinjha, R. K., Lewis, H. D., Mander, P. K. & De Winther, M. P. J. Front Pharmacol. 2019 Oct 29;10:1242. doi: 10.3389/fphar.2019.01242. eCollection 2019.      

22           Induction of Inflammation and Fibrosis by Semaphorin 4A in Systemic Sclerosis. Carvalheiro, T., Affandi, A. J., Malvar-Fernández, B., Dullemond, I., Cossu, M., Ottria, A., Mertens, J. S., Giovannone, B., Bonte-Mineur, F., Kok, M. R., Marut, W., Reedquist, K. A., Radstake, T. R. & García, S.Arthritis Rheumatol. 2019 Oct;71(10):1711-1722. doi: 10.1002/art.40915 2 12 p.          

23           Stimulation of Collateral Vessel Growth by Inhibition of Galectin 2 in Mice Using a Single-Domain Llama-Derived Antibody. Hollander MR, Jansen MF, Hopman LHGA, Dolk E, van de Ven PM, Knaapen P, Horrevoets AJ, Lutgens E, van Royen N. J Am Heart Assoc. 2019 Oct 15;8(20):e012806. doi: 10.1161/JAHA.119.012806 J Am Heart Assoc. 2019 Oct 15;8(20):e012806. doi: 10.1161/JAHA.119.012806.       

24           Systematic Dual Targeting of Dendritic Cell C-Type Lectin Receptor DC-SIGN and TLR7 Using a Trifunctional Mannosylated Antigen. Li RE, Hogervorst TP, Achilli S, Bruijns SC, Arnoldus T, Vivès C, Wong CC, Thépaut M, Meeuwenoord NJ, van den Elst H, Overkleeft HS, van der Marel GA, Filippov DV, van Vliet SJ, Fieschi F, Codée JDC, van Kooyk Y. Front Chem. 2019 Oct 4;7:650. doi: 10.3389/fchem.2019.00650. eCollection 2019.      

25           Monocytes co-cultured with reconstructed keloid and normal skin models skew towards M2 macrophage phenotype. Limandjaja, G. C., Waaijman, T., Roffel, S., Niessen, F. B. & Gibbs, S. Arch Dermatol Res. 2019 Oct;311(8):615-627. doi: 10.1007/s00403-019-01942-9                

26           Pharmacological PAR-1 inhibition reduces blood glucose levels but does not improve kidney function in experimental type 2 diabetic nephropathy. Waasdorp, M., Florquin, S., Duitman, J. & Spek, C. A. FASEB J. 2019 Oct;33(10):10966-10972. doi: 10.1096/fj.201900516R  

27           Method comparison for N-glycan profiling: Towards the standardization of glycoanalytical technologies for cell line analysis. Kotsias, M., Blanas, A., van Vliet, S. J., Pirro, M., Spen-cer, D. I. R. & Kozak, R. P. PLoS One. 2019 Oct 7;14(10):e0223270. doi: 10.1371/journal.pone.0223270. eCollection 2019.        

28           Glioblastoma-Associated Microglia Reprogramming Is Mediated by Functional Transfer of Extracellular miR-21 Abels, E. R., Maas, S. L. N., Nieland, L., Wei, Z., Cheah, P. S., Tai, E., Kolsteeg, C-J., Dusoswa, S. A., Ting, D. T., Hickman, S., el Khoury, J., Krichevsky, A. M., Broekman, M. L. D. & Breakefield, X. O. Cell Rep. 2019 Sep 17;28(12):3105-3119.e7. doi: 10.1016/j.celrep.2019.08.036.         

29           Neutrophils as Suppressors of T Cell Proliferation: Does Age Matter? Aarts CEM, Hiemstra IH, Tool ATJ, van den Berg TK, Mul E, van Bruggen R, Kuijpers TW.  Front Immunol. 2019 Sep 11;10:2144. doi: 10.3389/fimmu.2019.02144. eCollection 2019.

30           Disturbed remodeling and delayed fracture healing in pediatric pycnodysostosis pa-tients Grewal, S., Kilic, Ö., Savci-Heijink, C. D. & Kloen, P. J Orthop. 2019 Apr 15;16(5):373-377. doi: 10.1016/j.jor.2019.03.022. eCollection 2019 Sep-Oct.             

31           Glycan-Modified Apoptotic Melanoma-Derived Extracellular Vesicles as Antigen Source for Anti-Tumor Vaccination. Horrevorts SK, Stolk DA, van de Ven R, Hulst M, van Het Hof B, Duinkerken S, Heineke MH, Ma W, Dusoswa SA, Nieuwland R, Garcia-Vallejo JJ, van de Loosdrecht AA, de Gruijl TD, van Vliet SJ, van Kooyk Y.  Cancers (Basel). 2019 Aug 28;11(9). pii: E1266. doi: 10.3390/cancers11091266.

32           Early progression to active tuberculosis is a highly heritable trait driven by 3q23 in Peruvi-ans. Luo Y, Suliman S, Asgari S, Amariuta T, Baglaenko Y, Martínez-Bonet M,Ishigaki K, Gutierrez-Arcelus M, Calderon R, Lecca L, León SR, Jimenez J, Yataco R, Contreras C, Galea JT, Becerra M, Nejentsev S, Nigrovic PA, Moody DB, Murray MB, Raychaudhuri S.  Nat Commun. 2019 Aug;10(1):3765. doi: 10.1038/s41467-019-11664-1.        

33           Skin metabolism phase I and phase II enzymes in native and reconstructed human skin: a short review. Kazem, S., Linssen, E. C. & Gibbs, S. Drug Discov Today. 2019 Sep;24(9):1899-1910. doi: 10.1016/j.drudis.2019.06.002.

34           Efficient Innate Immune Killing of Cancer Cells Triggered by Cell-Surface Anchoring of Multi-valent Antibody-Recruiting Polymers. Uvyn, A., de Coen, R., Gruijs, M., Tuk, C. W., de Vrieze, J., van Egmond, M. & de Geest, B. G. Angew Chem Int Ed Engl. 2019 Sep 9;58(37):12988-12993. doi: 10.1002/anie.201905093            

35           Low RUNX3 expression alters dendritic cell function in patients with systemic sclerosis and contributes to enhanced fibrosis Affandi, A. J., Carvalheiro, T., Ottria, A., Broen, J. C. A., Bossini-Castillo, L., Tieland, R. G., Bon, L. V., Chouri, E., Rossato, M., Mertens, J. S., Gar-cia, S., Pandit, A., de Kroon, L. M. G., Christmann, R. B., Martin, J., van Roon, J. A. G., Radstake, T. R. D. J. & Marut, W. Annals of the Rheumatic Diseases. Sep 2019. 78, 9, p. 1249-1259          

36           Identification of genetic biomarkers for alloimmunization in sickle cell disease. Br J Haema-tol. Meinderts SM, Gerritsma JJ, Sins JWR, de Boer M, van Leeuwen K, Biemond BJ,Rijneveld AW, Kerkhoffs JH, Habibi A, van Bruggen R, Kuijpers TW, van der Schoot E, Pirenne F, Fijnvandraat K, Tanck MW, van den Berg TK. Br J Haematol. 2019 Sep;186(6):887-899. doi: 10.1111/bjh.15998     

37           Rewiring of immune-metabolic crosstalk in the liver after viral infection. de Goede KE, Van den Bossche J. J Mol Med (Berl). 2019 Sep;97(9):1245-1246. doi: 10.1007/s00109-019-01825-6.               

38           Detection of human IgM and IgG antibodies by means of galactofuranose-coated and rham-nose-coated gold nanoparticles. Wang, X., Chen, H., Chiodo, F. & Tefsen, B. Matters. Aug. 2019.  

39           Commensal and Pathogenic Biofilms Alter Toll-Like Receptor Signaling in Reconstructed Hu-man Gingiva. Shang, L., Deng, D., Buskermolen, J. K., Roffel, S., Janus, M. M., Krom, B. P., Crielaard, W. & Gibbs, S.  Front Cell Infect Microbiol. 2019 Aug 7;9:282. doi: 10.3389/fcimb.2019.00282. eCollection 2019.             

40           Induction of brain-infiltrating T-bet-expressing B cells in multiple sclerosis. van Langelaar J, Rijvers L, Janssen M, Wierenga-Wolf AF, Melief MJ, Siepman TA, de Vries HE, Unger PA, van Ham SM, Hintzen RQ, van Luijn MM. Ann Neurol. 2019 Aug;86(2):264-278. doi: 10.1002/ana.25508.         

41           Glycan modification of glioblastoma-derived extracellular vesicles enhances receptor-mediated targeting of dendritic cells. Dusoswa SA, Horrevorts SK, Ambrosini M, Kalay H, Paauw NJ, Nieuwland R, Pegtel MD, Würdinger T, Van Kooyk Y, Garcia-Vallejo JJ.  J. Extracell Vesicles. 2019 Aug 9;8(1):1648995. doi: 10.1080/20013078.2019.1648995. eCol-lection 2019.          

42           Glyco-Dendrimers as Intradermal Anti-Tumor Vaccine Targeting Multiple Skin DC Subsets. Duinkerken S, Horrevorts SK, Kalay H, Ambrosini M, Rutte L, de Gruijl TD, Garcia-Vallejo JJ, van Kooyk Y. Theranostics. 2019 Aug 12;9(20):5797-5809. doi: 10.7150/thno.35059. eCollection 2019.            

43           Synthetic, Zwitterionic Sp1 Oligosaccharides Adopt a Helical Structure Crucial for Antibody Interaction. Zhang, Q., Gimeno, A., Santana, D., Wang, Z., Valdés-Balbin, Y., Rodríguez-Noda, L. M., Hansen, T., Kong, L., Shen, M., Overkleeft, H. S., Vérez-Bencomo, V., van der Marel, G. A., Jiménez-Barbero, J., Chiodo, F. & Codée, J. D. C.  ACS Cent Sci. 2019 Aug 28;5(8):1407-1416. doi: 10.1021/acscentsci.9b00454.       

44           Mesangial deposition can strongly involve innate-like iga molecules lacking affinity matura-tion. Wehbi, B., Oblet, C., Boyer, F., Huard, A., Druilhe, A., Paraf, F., Cogné, E., Moreau, J., Makhour, Y. E., Badran, B., van Egmond, M., Cogné, M. & Aldigier, J-C. Am Soc Nephrol. 2019 Jul;30(7):1238-1249. doi: 10.1681/ASN.2018111089   

45           Liver X Receptor Alpha Is Important in Maintaining Blood-Brain Barrier Function. Wouters, E., de Wit, N. M., Vanmol, J., van der Pol, S. M. A., van Het Hof, B., Sommer, D., Loix, M., Geerts, D., Gustafsson, J. A., Steffensen, K. R., Vanmierlo, T., Bogie, J. F. J., Hendriks, J. J. A. & de Vries, H. E. Front Immunol. 2019 Jul 31;10:1811. doi: 10.3389/fimmu.2019.01811. eCollection 2019.

46           Alveolar macrophage apoptosis-associated bacterial killing helps prevent murine pneumonia Preston, J. A., Bewley, M. A., Marriott, H. M., Houghton, A. M., Mohasin, M., Jubrail, J., Morris, L., Stephenson, Y. L., Cross, S., Greaves, D. R., Craig, R. W., van Rooijen, N., Bin-gle, C. D., Read, R. C., Mitchell, T. J., Whyte, M. K. B., Shapiro, S. D. & Dockrell, D. H. Am J Respir Crit Care Med. 2019 Jul 1;200(1):84-97. doi: 10.1164/rccm.201804-0646OC.               

47           BOB.1 controls memory B-cell fate in the germinal center reaction. Levels, M. J., Fehres, C. M., van Baarsen, L. G. M., van Uden, N. O. P., Germar, K., O'Toole, T. G., Blijdorp, I. C. J., Semmelink, J. F., Doorenspleet, M. E., Bakker, A. Q., Krasavin, M., Tomilin, A., Brouard, S., Spits, H., Baeten, D. L. P. & Yeremenko, N. G. J Autoimmun. 2019 Jul;101:131-144. doi: 10.1016/j.jaut.2019.04.011.   

48           Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Soci-ety of Cardiology. Ketelhuth, D. F. J., Lutgens, E., Bäck, M., Binder, C. J., Van den Bossche, J., Daniel, C., Dumitriu, I. E., Hoefer, I., Libby, P., O'Neill, L., Weber, C. & Evans, P. C., 1 Cardiovascular Research. Cardiovasc Res. 2019 Jul 1;115(9):1385-1392. doi: 10.1093/cvr/cvz166.     

49           Targeting the cell cycle in head and neck cancer by Chk1 inhibition: a novel concept of bi-modal cell death. van Harten, A. M., Buijze, M., van der Mast, R., Rooimans, M. A., Martens-de Kemp, S. R., Bachas, C., Brink, A., Stigter-van Walsum, M., Wolthuis, R. M. F. & Brakenhoff, R. H. Oncogenesis. 2019 Jun 17;8(7):38. doi: 10.1038/s41389-019-0147-x            

50           Dietary sodium-induced blood pressure rise is associated with a pro-inflammatory phenotype of classical monocytes – a randomized controlled trial in healthy human subjects. Wenstedt, E., Wouda, R., Schrooten, E., Rademaker, E., Rorije, N., van den Bossche, J. & Vogt, L. Journal of Hypertension. Jul 2019. 37, p. e75-e76          

51           Macrophage galactose-type lectin (MGL) is induced on M2 microglia and participates in the resolution phase of autoimmune neuroinflammation. Ilarregui JM, Kooij G, Rodríguez E, van der Pol SMA, Koning N, Kalay H, van der Horst JC, van Vliet SJ, García-Vallejo JJ, de Vries HE, van Kooyk Y. Neuroinflammation. 2019 Jun 27;16(1):130. doi: 10.1186/s12974-019-1522-4.    

52           Hypertrophic and keloid scars fail to progress from the CD34−/α-smooth muscle actin (α-SMA)+ immature scar phenotype and show gradient differences in α-SMA and p16 expression. Limandjaja, G. C., Belien, J. M., Scheper, R. J., Niessen, F. B. & Gibbs, S. Br J Dermatol. 2020 Apr;182(4):974-986. doi: 10.1111/bjd.18219         

53           Neutrophils acquire antigen-presenting cell features after phagocytosis of IgG-opsonized erythrocytes. Meinderts SM, Baker G, van Wijk S, Beuger BM, Geissler J, Jansen MH, Saris A, Ten Brinke A, Kuijpers TW, van den Berg TK, van Bruggen R. Blood Adv. 2019 Jun 11;3(11):1761-1773. doi:10.1182/bloodadvances.2018028753.               

54           Let's Enter the Wonderful World of Immunometabolites. de Goede KE, Harber KJ, Van den Bossche J. Trends Endocrinol Metab. 2019 Jun;30(6):329-331. doi: 10.1016/j.tem.2019.03.004.    

55           Outer membrane vesicles engineered to express membrane-bound antigen program dendritic cells for cross-presentation to CD8(+) T cells. Schetters STT, Jong WSP, Horrevorts SK, Kruijssen LJW, Engels S, Stolk D, Daleke-Schermerhorn MH, Garcia-Vallejo J, Houben D, Un-ger WWJ, den Haan JMM, Luirink J, van Kooyk Y. Acta Biomater. 2019 Jun;91:248-257. doi: 10.1016/j.actbio.2019.04.033.            

56           Circadian glucocorticoid oscillations preserve a population of adult hippocampal neural stem cells in the aging brain. Schouten M, Bielefeld P, Garcia-Corzo L, Passchier EMJ, Gra-dari S, Jungenitz T, Pons-Espinal M, Gebara E, Martín-Suárez S, Lucassen PJ, De Vries HE, Trejo JL, Schwarzacher SW, De Pietri Tonelli D, Toni N, Mira H, Encinas JM, Fitzsimons CP. Mol Psychiatry. 2019 Jun 20. doi: 10.1038/s41380-019-0440-2.  

57           Regenerative potential of adipocytes in hypertrophic scars is mediated by myofibroblast re-programming. Hoerst, K., van den Broek, L., Erdmann, G., Klein, O., von Fritschen, U., Gibbs, S. & Hedtrich, S. J Mol Med (Berl). 2019 Jun;97(6):761-775. doi: 10.1007/s00109-019-01772-2.

58           Human saliva stimulates skin and oral wound healing in vitro. Rodrigues Neves, C., Busk-ermolen, J., Roffel, S., Waaijman, T., Thon, M., Veerman, E. & Gibbs, S.  J Tissue Eng Regen Med. 2019 Jun;13(6):1079-1092. doi: 10.1002/term.2865       

59           Myeloid immune-checkpoint inhibition enters the clinical stage. van den Berg TK, Valerius T. Nat Rev Clin Oncol. 2019 May;16(5):275-276. doi: 10.1038/s41571-018-0155-3.        

60           Novel IL2RG Mutation Causes Leaky TLOWB+NK+ SCID With Nodular Regenerative Hyperplasia and Normal IL-15 STAT5 Phosphorylation. Neves, J. F., Martins, C., Cordeiro, A. I., Neves, C., Plagnol, V., Curtis, J., Fabre, M., Bibi, S., Borrego, L. M., Moshous, D., Nejentsev, S. & Gilmour, K. J Pediatr Hematol Oncol. 2019 May;41(4):328-333. doi: 10.1097/MPH.0000000000001232         

61           The peritoneal surface proteome in a model of chronic peritoneal dialysis reveals mecha-nisms of membrane damage and preservation Boehm, M., Herzog, R., Klinglmüller, F., Lichtenauer, A. M., Wagner, A., Unterwurzacher, M., Beelen, R. H. J., Alper, S. L., Aufricht, C. & Kratochwill, K. Front Physiol. 2019 May 14;10:472. doi: 10.3389/fphys.2019.00472. eCollection 2019.  

62           Bi-allelic Loss-of-Function CACNA1B Mutations in Progressive Epilepsy-Dyskinesia. Gorman KM, Meyer E, Grozeva D, Spinelli E, McTague A, Sanchis-Juan A, Carss KJ, Bryant E, Reich A, Schneider AL, Pressler RM, Simpson MA, Debelle GD, Wassmer E, Morton J, Sieciechowicz D, Jan-Kamsteeg E, Paciorkowski AR, King MD, Cross JH, Poduri A, Mefford HC, Scheffer IE, Haack TB, McCullagh G; Deciphering; Nejentsev S Developmental Disorders Study; UK10K Consortium; NIHR BioResource, Millichap JJ, Carvill GL, Clayton-Smith J, Maher ER, Raymond FL, Kurian MA. Am J Hum Genet. 2019 May 2;104(5):948-956. doi: 10.1016/j.ajhg.2019.03.005.   

63           Metabolic-epigenetic crosstalk in macrophage activation: An updated view Verberk, S. G. S., De Goede, K. E. & Van Den Bossche, J. Epigenomics. 2019 May;11(7):719-721. doi: 10.2217/epi-2019-0073.           

64           Differential effects of anaphylatoxin C5a on antigen presenting cells, roles for C5aR1 and C5aR2. Zaal, A., van Ham, S. M. & ten Brinke, A. Immunol Lett. 2019 May;209:45-52. doi: 10.1016/j.imlet.2019.03.014          

65           Disruption of sialic acid metabolism drives tumor growth by augmenting CD8+ T cell apopto-sis Cornelissen, L. A. M., Blanas, A., van der Horst, J. C., Kruijssen, L., Zaal, A., O'Toole, T., Wiercx, L., van Kooyk, Y. & van Vliet, S. J. Int J Cancer. 2019 May 1;144(9):2290-2302. doi: 10.1002/ijc.32084.                

66           Reduced angiopoietin-like 4 expression in multiple sclerosis lesions facilitates lipid uptake by phagocytes via modulation of lipoprotein-lipase activity. Kamermans, A., Rijnsburger, M., Chakraborty, A., van der Pol, S., de Vries, H. E. & van Horssen. J. Front Immunol. 2019 May 3;10:950. doi: 10.3389/fimmu.2019.00950. eCollection 2019.     

67           Dierproeven binnen de tandheelkunde: zielig of essentieel? Interview van de Wardt, E. & Gibbs, S. Dental Tribune. May 2019.       

68           A comprehensive proteomics study on platelet concentrates: Platelet proteome, storage time and Mirasol pathogen reduction technology. Salunkhe, V., De Cuyper, I. M., Papadopou-los, P., van der Meer, P. F., Daal, B. B., Villa-Fajardo, M., de Korte, D., van den Berg, T. K. & Gutiérrez, L.  Platelets. 2019;30(3):368-379. doi: 10.1080/09537104.2018.1447658          

69           Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy. Logtenberg MEW, Jansen JHM, Raaben M, Toebes M, Franke K, Brandsma AM, Matlung HL, Fauster A, Gomez-Eerland R, Bakker NAM, van der Schot S, Marijt KA, Verdoes M, Haanen JBAG, van den Berg JH, Neefjes J, van den Berg TK, Brummelkamp TR,Leusen JHW, Scheeren FA, Schumacher TN. Nat Med. 2019 Apr;25(4):612-619. doi: 10.1038/s41591-019-0356-z.    

70           Identification of a secondary binding site in human macrophage galactose-type lectin by microarray studies: Implications for the molecular recognition of its ligands.1: Marcelo F, Supekar N, Corzana F, van der Horst JC, Vuist IM, Live D, Boons GPH, Smith DF, van Vliet SJ. J Biol Chem. 2019 Jan 25;294(4):1300-1311. doi: 10.1074/jbc.RA118.004957