Publications 2018

1. Effluent and serum protein N-glycosylation is associated with inflammation and peritoneal membrane transport characteristics in peritoneal dialysis patients. Ferrantelli, E., Farhat, K., Ederveen, A. L. H., Reiding, K. R., Beelen, R. H. J., Van Ittersum, F. J., Wuhrer, M. & Dotz, V., 1 Dec 2018, In : Scientific Reports. 8, 1, 979

2. Associations between traumatic stress symptoms, pain and bio-active components in burn wounds. Van Loey, N. E., Hofland, H. W. C., Vlig, M., Vandermeulen, E., Rose, T., Beelen, R. H. J. & Ulrich, M. M. W., 1 Oct 2018, In : Psychoneuroendocrinology. 96, p. 1-5 5 p.

3. Modulation of Immune Tolerance via Siglec-Sialic Acid Interactions.  Lübbers, J., Rodríguez, E. &   van Kooyk, Y., Dec 2018, In : Frontiers in Immunology. 9, p. 2807-2820    13 p. Research output: Contribution to journal › Article › Academic › peer-review

4. A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia. Baardman, J., Verberk, S. G. S., Prange, K. H. M., van Weeghel, M., van der Velden, S., Ryan, D. G., Wüst, R. C. I., Neele, A. E., Speijer, D., Denis, S. W., Witte, M. E., Houtkooper, R. H., O'neill, L. A., Knatko, E. V., Dinkova-Kostova, A. T., Lutgens, E., de Winther, M. P. J. & Van den Bossche, J., 20 Nov 2018, In : Cell Reports. 25, 8, p. 2044-2052.e5

5. Elevated monocyte-specific type I interferon signalling correlates positively with cardiac healing in myocardial infarct patients but interferon alpha application deteriorates myocardial healing in rats. Ter Horst, E. N., Krijnen, P. A. J., Hakimzadeh, N., Robbers, L. F. H. J., Hirsch, A., Nijveldt, R., Lommerse, I., Fontijn, R. D., Meinster, E., Delewi, R., van Royen, N., Zijlstra, F., van Rossum, A. C., van der Schoot, C. E., van der Pouw Kraan, T. C. T. M., Horrevoets, A. J., van der Laan, A. M., Niessen, H. W. M. & Piek, J. J., 12 Nov 2018, In : Basic Research in Cardiology. 114, 1, p. 1

6. Complexity of Lymphoid Tissue Organizers: A Response to Onder and Ludewig. Koning, JJ. & Mebius, RE., 2 Nov 2018, In : Trends in Immunology.

7. Monoclonal antibody-mediated killing of tumour cells by neutrophils. Heemskerk, N. & van Egmond, M., 1 Nov 2018, In : European Journal of Clinical Investigations. 48

8. Fc gamma receptor IIa suppresses type I and III interferon production by human myeloid immune cells Newling, M., Hoepel, W., Vogelpoel, L. T. C., Heineke, M. H., van Burgsteden, J. A., Taanman-Kueter, E. W. M., Eggink, D., Kuijpers, T. W., Beaumont, T., van Egmond, M., Kapsenberg, M. L., Baeten, D. L. P., den Dunnen, J. & Jong, E. C. D., Nov 2018, In : European Journal of Immunology. 48, 11, p. 1796-1809 14 p.

9. Multi-species oral biofilm promotes reconstructed human gingiva epithelial barrier function. Shang, L., Deng, D., Buskermolen, J. K., Janus, M. M., Krom, B. P., Roffel, S., Waaijman, T., van Loveren, C., Crielaard, W. & Gibbs, S., 30 Oct 2018, In : Scientific Reports. 8, 1

10. IFNα Impairs Autophagic Degradation of mtDNA Promoting Autoreactivity of SLE Monocytes in a STING-Dependent Fashion. Gkirtzimanaki, K., Kabrani, E., Nikoleri, D., Polyzos, A., Blanas, A., Sidiropoulos, P., Makrigiannakis, A., Bertsias, G., Boumpas, D. & Verginis, P., 23 Oct 2018, In : Cell Reports.

11. Glycans to reprogram the immune response. Li, RJE., van Kooyk, Y. & van Vliet, SJ., 22 Oct 2018, Atlas of Science. 1 p.

12. Transcriptional activation of fucosyltransferase (FUT) genes using the CRISPR-dCas9-VPR technology reveals potent N-glycome alterations in colorectal cancer cells. Blanas, A., Cornelissen, LAM., Kotsias, M., Horst, J., Vrugt, H., Kalay, H., Spencer, D., Kozak, R. & van Vliet, SJ., 16 Oct 2018, In : Glycobiology. 2019 Feb 1;29(2):137-150. doi:10.1093/glycob/CW096.

13. Fatty Acid Oxidation in Macrophages and T Cells: Time for Reassessment? Van den Bossche, J. & van der Windt, G. J. W., 2 Oct 2018, In : Cell Metabolism. 28, 4, p. 538-540 3 p.

14. Genetic correlations among psychiatric and immune-related phenotypes based on genome-wide association data 23 and Me Research Team, Oct 2018, In : American Journal of Medical Genetics Part BNeuropsychiatric Genetics. 177, 7, p. 641-657 17 p.

15. Immobilization of β-galactosidase and α-mannosidase onto magnetic nanoparticles: A strategy for increasing the potentiality of valuable glycomic tools for glycosylation analysis and biological role determination of glycoconjugates. Rodríguez, E., Francia, K., Brossard, N., García Vallejo, J. J., Kalay, H., van Kooyk, Y., Freire, T. & Giacomini, C., Oct 2018, In : Enzyme and microbial technology. 117, p. 45-55 11 p.

16. Dynamics of Transcription Regulation in Human Bone Marrow Myeloid Differentiation to Mature Blood Neutrophils. Grassi, L. , Pourfarzad, F. , Ullrich, S. , Merkel, A. , Were, F. , Carrillo-de-Santa-Pau, E. , Yi, G. , Hiemstra, I. H. , Tool, A. T. J. , Mul, E. , Perner, J. , Janssen-Megens, E. , Berentsen, K. , Kerstens, H. , Habibi, E. , Gut, M. , Yaspo, M. L. , Linser, M. , Lowy, E. , Datta, A. & 15 others Clarke, L., Flicek, P., Vingron, M., Roos, D., van den Berg, T. K., Heath, S., Rico, D., Frontini, M., Kostadima, M., Gut, I., Valencia, A., Ouwehand, W. H., Stunnenberg, H. G., Martens, J. H. A. & Kuijpers, T. W., 4 Sep 2018, In : Cell Reports. 24, 10, p. 2784-2794 11 p.

17. Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation. Cuchet-Lourenço, D. , Eletto, D. , Wu, C. , Plagnol, V. , Papapietro, O. , Curtis, J. Ceron-Gutierrez, L. , Bacon, C. M. , Hackett, S. , Alsaleem, B. , Maes, M. , Gaspar, M. , Alisaac, A. , Goss, E. , AlIdrissi, E. , Siegmund, D. , Wajant, H. , Kumararatne, D. , AlZahrani, M. S. , Arkwright, P. D. & 3 others Abinun, M., Doffinger, R. & Nejentsev, S., 24 Aug 2018, In : Science. 361, 6404, p. 810-813 4 p.

18.  Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogramming of Mitochondrial Metabolism. Koenis, D. S., Medzikovic, L., van Loenen, P. B., van Weeghel, M., Huveneers, S., Vos, M., Evers-van Gogh, I. J., Van den Bossche, J., Speijer, D., Kim, Y., Wessels, L., Zelcer, N., Zwart, W., Kalkhoven, E. & de Vries, C. J., 21 Aug 2018, In : Cell Reports. 24, 8, p. 2127-2140.e7

19.  PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner. Stark, A-K., Chandra, A., Chakraborty, K., Alam, R., Carbonaro, V., Clark, J., Sriskantharajah, S., Bradley, G., Richter, A. G., Banham-Hall, E., Clatworthy, M. R., Nejentsev, S., Hamblin, J. N., Hessel, E. M., Condliffe, A. M. & Okkenhaug, K., 9 Aug 2018, In : Nature Communications. 9, 1, p. 3174

20. Myeloid Kdm6b deficiency results in advanced atherosclerosis. Neele, A. E., Gijbels, M. J. J., van der Velden, S., Hoeksema, M. A., Boshuizen, M. C. S., Prange, K. H. M., Chen, H-J., Van den Bossche, J., van Roomen, C. P. P. A., Shami, A., Levels, J. H. M., Kroon, J., Lucas, T., Dimmeler, S., Lutgens, E. & de Winther, M. P. J., Aug 2018, In : Atherosclerosis. 275, p. 156-165 10 p.

21. Toll-Like Receptor 4 Triggering Promotes Cytosolic Routing of DC-SIGN-Targeted Antigens for Presentation on MHC Class I. Horrevorts, S. K., Duinkerken, S., Bloem, K., Secades, P., Kalay, H., Musters, R. J., van Vliet, S. J., García-Vallejo, J. J. & van Kooyk, Y., 14 Jun 2018, In : Frontiers in Immunology. 9, p. 1231

22. Red pulp macrophages in the human spleen are a distinct cell population with a unique expression of Fc-γ receptors. Nagelkerke, S. Q., Bruggeman, C. W., den Haan, J. M. M., Mul, E. P. J., van den Berg, T. K., van Bruggen, R. & Kuijpers, T. W., 24 Apr 2018, In : BLOOD ADVANCES. 2, 8, p. 941-953 13 p.

23. Active liver X receptor signaling in phagocytes in multiple sclerosis lesions. Mailleux, J., Vanmierlo, T., Bogie, J. F., Wouters, E., Lütjohann, D., Hendriks, J. J. & van Horssen, J.,Mar 2018, In : Multiple Sclerosis. 24, 3, p. 279-289 11 p.

24. A false-carrier state for the c.579G>A mutation in the NCF1 gene in Ashkenazi Jews. De Boer, M., Gavrieli, R., van Leeuwen, K., Wolf, H. R., Dushnitzki, M., Bar-Yosef, Y., Bar-Ziv, A., Behar, D., Lipitz, S., Miller, T. E., Tool, A. T. J., Kuijpers, T. W., van den Berg, T. K., Wolach, B., Roos, D. & Pras, E., Mar 2018, In : Journal of Medical Genetics. 55, 3, p. 166-172 7 p.

25. CD169 is a marker for highly pathogenic phagocytes in multiple sclerosis. Bogie, J. F., Boelen, E., Louagie, E., Delputte, P., Elewaut, D., van Horssen, J., Hendriks, J. J. & Hellings, N., Mar 2018, In : Multiple Sclerosis. 24, 3, p. 290-300 11 p.

26. Early cellular interactions and immune transcriptome profiles in human factor VIII-exposed hemophilia A mice. Lai, J. D., Cartier, D., Hartholt, R. B., Swystun, L. L., van Velzen, A. S., den Haan, J. M. M., Hough, C., Voorberg, J. & Lillicrap, D., Mar 2018, In : Journal of Thrombosis and Haemostasis. 16, 3, p. 533-545 13 p. Research output: Contribution to journal › Article › Academic › peer-review

27. The tumour glyco-code as a novel immune checkpoint for immunotherapy. RodrÍguez, E., Schetters, S. T. T. & van Kooyk, Y., Mar 2018, In : Nature Reviews Immunology. 18, 3, p. 204-211 8 p.

28. Biocompatible single-chain polymer nanoparticles loaded with an antigen mimetic as potential anticancer vaccine. Gracia, R., Marradi, M., Salerno, G., Pérez-Nicado, R., Pérez-San Vicente, A., Dupin, D., Rodriguez, J., Loinaz, I., Chiodo, F. & Nativi, C., 20 Feb 2018, In : ACS Macro Letters. 7, 2, p. 196-200 5 p.

29. Functional CD169 on Macrophages Mediates Interaction with Dendritic Cells for CD8+ T Cell Cross-Priming. van Dinther, D., Veninga, H., Iborra, S., Borg, E. G. F., Hoogterp, L., Olesek, K., Beijer, M. R., Schetters, S. T. T., Kalay, H., Garcia-Vallejo, J. J., Franken, K. L., Cham, L. B., Lang, K. S., van Kooyk, Y., Sancho, D., Crocker, P. R. & den Haan, J. M. M., 6 Feb 2018, In : Cell Reports. 22, 6, p. 1484-1495 12 p.

30. Loading dendritic cells with gold nanoparticles (GNPs) bearing HIV-peptides and mannosides enhance HIV-specific T cell responses. Climent, N., García, I., Marradi, M., Chiodo, F., Miralles, L., Maleno, M. J., Gatell, J. M., García, F., Penadés, S. & Plana, M., 1 Feb 2018, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 14, 2, p. 339-351 13 p.

31. Genetic variation of human neutrophil Fcγ receptors and SIRPα in antibody-dependent cellular cytotoxicity towards cancer cells. Treffers, L. W., Zhao, X. W., van der Heijden, J., Nagelkerke, S. Q., van Rees, D. J., Gonzalez, P., Geissler, J., Verkuijlen, P., van Houdt, M., de Boer, M., Kuijpers, T. W., van den Berg, T. K. & Matlung, H. L., Feb 2018, In : European Journal of Immunology. 48, 2, p. 344-354 11 p.

32. IgG is elevated in obese white adipose tissue but does not induce glucose intolerance via Fcγ-receptor or complement. van Dam, A. D., van Beek, L., Pronk, A. C. M., van den Berg, S. M., Van den Bossche, J., de Winther, M. P. J., Koning, F., van Kooten, C., Rensen, P. C. N., Boon, M. R., Verbeek, J. S., van Dijk, K. W. & van Research output: Contribution to journal › Article › Academic › peer-review

33. Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms. Pridgeon, C. S. , Schlott, C. , Wong, M. W. , Heringa, M. B. , Heckel, T. , Leedale, J. , Launay, L. , Gryshkova, V. , Przyborski, S. , Bearon, R. N. , Wilkinson, E. L. , Ansari, T. , Greenman, J. , Hendriks, D. F. G. , Gibbs, S. , Sidaway, J. , Sison-Young, R. L. , Walker, P. , Cross, M. J. , Park, B. K. & 1 others Goldring, C. E. P., Feb 2018, In : Archives of Toxicology. 92, 2, p. 557-569

34. Ascaris Suum Infection Downregulates Inflammatory Pathways in the Pig Intestine in Vivo and in Human Dendritic Cells in Vitro. Midttun, H. L. E., Acevedo, N., Skallerup, P., Almeida, S., Skovgaard, K., Andresen, L., Skov, S., Caraballo, L., Van DIe, I., Jørgensen, C. B., Fredholm, M., Thamsborg, S. M., Nejsum, P. & Williams, A. R., 15 Jan 2018, In : Journal of Infectious Diseases. 217, 2, p. 310-319 10 p.

35. Glycophorin-C sialylation regulates Lu/BCAM adhesive capacity during erythrocyte aging. Klei, T. R. L., de Back, D. Z., Asif, P. J., Verkuijlen, P. J. J. H., Veldthuis, M., Ligthart, P. C., Berghuis, J., Clifford, E., Beuger, B. M., van den Berg, T. K., van Zwieten, R., El Nemer, W. & van Bruggen, R., 9 Jan 2018, In : BLOOD ADVANCES. 2, 1, p. 14-24 11 p.

36. Activated PI3 Kinase Delta Syndrome: From Genetics to Therapy. Michalovich, D. & Nejentsev, S., 2018, In : Frontiers in Immunology. 9, p. 369

37. Angiopoietin like-4 as a novel vascular mediator in capillary cerebral amyloid angiopathy. Chakraborty, A., Kamermans, A., van Het Hof, B., Castricum, K., Aanhane, E., van Horssen, J., Thijssen, V. L., Scheltens, P., Teunissen, C. E., Fontijn, R. D., van der Flier, W. M. & de Vries, H. E., 2018, In : Brain : a journal of neurology. 141, 12, p. 3377-3388 12 p.

38. Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery. Ewart, L., Dehne, E-M., Fabre, K., Gibbs, S., Hickman, J., Hornberg, E., Ingelman-Sundberg, M., Jang, K-J., Jones, D. R., Lauschke, V. M., Marx, U., Mettetal, J. T., Pointon, A., Williams, D., Zimmermann, W-H. & Newham, P., 2018, In : Annual Review of Pharmacology and Toxicology. 58, p. 65-82

39. CD169+ Macrophages Capture and Dendritic Cells Instruct: The Interplay of the Gatekeeper and the General of the Immune System. Grabowska, J., Lopez-Venegas, M. A., Affandi, A. J. & den Haan, J. M. M., 2018, In : Frontiers in Immunology. 9, p. 2472

40. Comparison of Protein and Peptide Targeting for the Development of a CD169-Based Vaccination Strategy Against Melanoma. van Dinther, D., Veninga, H., Revet, M., Hoogterp, L., Olesek, K., Grabowska, J., Borg, E. G. F., Kalay, H., van Kooyk, Y. & den Haan, J. M. M., 2018, In : Frontiers in Immunology. 9, p. 1997

41. Corrigendum: Fucosylated Antigens in Cancer: An Alliance Toward Tumor Progression, Metastasis, and Resistance to Chemotherapy. Blanas, A., Sahasrabudhe, N. M., Rodríguez, E., van Kooyk, Y. & van Vliet, S. J., 2018, In : Frontiers in Oncology. 8, MAY, 150

42. Dendritic Cell Migration to Skin-Draining Lymph Nodes Is Controlled by Dermatan Sulfate and Determines Adaptive Immunity Magnitude. Nadafi, R., Koning, J. J., Veninga, H., Stachtea, X. N., Konijn, T., Zwiers, A., Malmström, A., den Haan, J. M. M., Mebius, R. E., Maccarana, M. & Reijmers, R. M., 2018, In : Frontiers in Immunology. 9, p. 206

43. Development of an In Vitro Method to Estimate the Sensitization Induction Level of Contact Allergens. Galbiati, V., Gibbs, S., Roggen, E. & Corsini, E., 2018, In : Current protocols in toxicology. 75, p. 20.15.1-20.15.20

44. Extracellular RNAs: A new awareness of old perspectives. Sadik, N., Cruz, L., Gurtner, A., Rodosthenous, R. S., Dusoswa, S. A., Ziegler, O., van Solinge, T. S., Wei, Z., Salvador-Garicano, A. M., Gyorgy, B., Broekman, M. & Balaj, L., 2018, Methods in Molecular Biology. Humana Press Inc., Vol. 1740, p. 1-15 15 p. (Methods in Molecular Biology)

45. Fucosylated Antigens in Cancer: An Alliance toward Tumor Progression, Metastasis, and Resistance to Chemotherapy. Blanas, A., Sahasrabudhe, N. M., Rodríguez, E., van Kooyk, Y. & van Vliet, S. J., 2018, In : Frontiers in Oncology. 8, p. 39

46. Galectin-4, a Negative Regulator of Oligodendrocyte Differentiation, Is Persistently Present in Axons and Microglia/Macrophages in Multiple Sclerosis Lesions. de Jong, C. G. H. M., Stancic, M., Pinxterhuis, T. H., van Horssen, J., van Dam, A-M., Gabius, H-J. & Baron, W., 2018, In : Journal of Neuropathology and Experimental Neurology. 77, 11, p. 1024-1038 15 p.

47. IgG Glyco-Engineering to Improve IVIg Potency. Bruggeman, C. W., Dekkers, G., Visser, R., Goes, N. W. M., van den Berg, T. K., Rispens, T., Vidarsson, G. & Kuijpers, T. W., 2018, In : Frontiers in Immunology. 9, p. 2442

48. Impaired lymph node stromal cell function during the earliest phases of rheumatoid arthritis. Hähnlein, J. S., Nadafi, R., de Jong, T., Ramwadhdoebe, T. H., Semmelink, J. F., Maijer, K. I., Zijlstra, I. J. A., Maas, M., Gerlag, D. M., Geijtenbeek, T. B. H., Tak, P. P., Mebius, R. E. & van Baarsen, L. G. M., 2018, In : Arthritis Research & Therapy. 20, 1, 35

49. Inherited p40phox deficiency differs from classic chronic granulomatous disease. van de Geer, A. , Nieto-Patlán, A. , Kuhns, D. B. , Tool, A. T. J. , Arias, A. A. , Bouaziz, M. , de Boer, M. , Franco, J. L. , Gazendam, R. P. , van Hamme, J. L. , van Houdt, M. , van Leeuwen, K. , Verkuijlen, P. J. H. , van den Berg, T. K. , Alzate, J. F. , Arango-Franco, C. A. , Batura, V. , Bernasconi, A. R. , Boardman, B. , Booth, C. & 39 others Burns, S. O., Cabarcas, F., Bensussan, N. C., Charbit-Henrion, F., Corveleyn, A., Deswarte, C., Azcoiti, M. E., Foell, D., Gallin, J. I., Garcés, C., Guedes, M., Hinze, C. H., Holland, S. M., Hughes, S. M., Ibañez, P., Malech, H. L., Meyts, I., Moncada-Velez, M., Moriya, K., Neves, E., Oleastro, M., Perez, L., Rattina, V., Oleaga-Quintas, C., Warner, N., Muise, A. M., López, J. S., Trindade, E., Vasconcelos, J., Vermeire, S. V., Wittkowski, H., Worth, A., Abel, L., Dinauer, M. C., Arkwright, P. D., Roos, D., Casanova, J-L., Kuijpers, T. W. & Bustamante, J., 2018, In : Journal of Clinical Investigation. 128, 9, p. 3957-3975

50. Innate Lymphoid Cells: 10 Years On. Vivier, E., Artis, D., Colonna, M., Diefenbach, A., di Santo, J. P., Eberl, G. R., Koyasu, S., Locksley, R. M., McKenzie, A. N. J., Mebius, R. E., Powrie, F. & Spits, H., 2018, In : Cell. 174, 5, p. 1054-1066 13 p.

51. Interferon Gamma-Induced Protein (IP-10) as Potential Biomarker for Cancer-Related-Fatigue: Results from a 6-month Randomized Controlled Trial. ter Veer, E., Prinsen, H., Sprangers, M. A. G., Zwinderman, K. A. H., Bleijenberg, G., van der Pouw Kraan, T. C. T. M., de Vries, I. J. M., Wierenga, E. A. & van Laarhoven, H. W. M., 2018, In : Cancer Investigation. 36, 7, p. 371-377

52. Lectin-mediated binding and sialoglycans of porcine surfactant protein D synergistically neutralize influenza A virus. van Eijk, M., Rynkiewicz, M. J., Khatri, K., Leymarie, N., Zaia, J., White, M. R., Hartshorn, K. L., Cafarella, T. R., van Die, I., Hessing, M., Seaton, B. A. & Haagsman, H. P., 2018, In : Journal of Biological Chemistry. 293, 27, p. 10646-10662

53. Mouse DC-SIGN/CD209a as Target for Antigen Delivery and Adaptive Immunity. Schetters, S. T. T., Kruijssen, L. J. W., Crommentuijn, M. H. W., Kalay, H., Ochando, J., den Haan, J. M. M., Garcia-Vallejo, J. J. & van Kooyk, Y., 2018, In : Frontiers in Immunology. 9, p. 990

54. Neuroinflammation: Microglia and T Cells Get Ready to Tango. Schetters, S. T. T., Gomez-Nicola, D., Garcia-Vallejo, J. J. & van Kooyk, Y., 2018, In : Frontiers in Immunology. 8, JAN, 1905

55. Oncogenic BRAFV600E drives expression of MGL ligands in the colorectal cancer cell line HT29 through N-acetylgalactosamine-transferase 3. Sahasrabudhe, N. M., Lenos, K., van der Horst, J. C., Rodríguez, E. & van Vliet, S. J., 2018, In : Biological Chemistry. 399, 7, p. 649-659 11 p.

56. Positive & negative roles of innate effector cells in controlling cancer progression. Stolk, D., van der Vliet, H. J., de Gruijl, T. D., van Kooyk, Y. & Exley, M. A., 2018, In : Frontiers in Immunology. 9, SEP, 1990

57. Spillage of bacterial products during colon surgery increases the risk of liver metastases development in a rat colon carcinoma model. Grewal, S., Korthouwer, R., Bögels, M., Braster, R., Heemskerk, N., Budding, A. E., Pouw, S. M., van Horssen, J., Ankersmit, M., Meijerink, J., van den Tol, P., Oosterling, S., Bonjer, J., Gül, N. & van Egmond, M., 2018, In : OncoImmunology. 7, 9, p. e1461302

58. Studying the blood–brain barrier will provide new insights into neurodegeneration – Yes. Kamphuis, W. W. & de Vries, H. E., 2018, In : Multiple Sclerosis Journal. 24, 8, p. 1023-1024

59. Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis. Seijkens, T. T. P. , van Tiel, C. M. , Kusters, P. J. H. , Atzler, D. , Soehnlein, O. , Zarzycka, B. , Aarts, S. A. B. M. , Lameijer, M. , Gijbels, M. J. , Beckers, L. , den Toom, M. , Slütter, B. , Kuiper, J. , Duchene, J. , Aslani, M. , Megens, R. T. A. , van ‘t Veer, C. , Kooij, G. , Schrijver, R. , Hoeksema, M. A. & 16 others Boon, L., Fay, F., Tang, J., Baxter, S., Jongejan, A., Moerland, P. D., Vriend, G., Bleijlevens, B., Fisher, E. A., Duivenvoorden, R., Gerdes, N., de Winther, M. P. J., Nicolaes, G. A., Mulder, W. J. M., Weber, C. & Lutgens, E., 2018, In : Journal of the American College of Cardiology. 71, 5, p. 527-542

60. Targeting Mycobacterium tuberculosis antigens to dendritic cells via the DC-specific-ICAM3-grabbing-nonintegrin receptor induces strong T-helper 1 immune responses. Velasquez, L. N., Stüve, P., Gentilini, M. V., Swallow, M., Bartel, J., Lycke, N. Y., Barkan, D., Martina, M., Lujan, H. D., Kalay, H., van Kooyk, Y., Sparwasser, T. D. & Berod, L., 2018, In : Frontiers in Immunology. 9, MAR, p. 471 471

61. T helper 17.1 cells associate with multiple sclerosis disease activity: Perspectives for early intervention. van Langelaar, J., van der Vuurst de Vries, R. M., Janssen, M., Wierenga-Wolf, A. F., Spilt, I. M., Siepman, T. A., Dankers, W., Verjans, G. M. G. M., de Vries, H. E., Lubberts, E., Hintzen, R. Q. & van Luijn, M. M., 2018, In : Brain. 141, 5, p. 1334-1349

62. The microenvironment in Barrett's esophagus tissue is characterized by high FOXP3 and RALDH2 levels. Lind, A., Siersema, P. D., Kusters, J. G., Konijn, T., Mebius, R. E. & Koenderman, L., 2018, In : Frontiers in Immunology. 9, JUN, 1375

63. Glucocorticoid-mediated modulation of morphological changes associated with aging in microglia. van Olst, L., Bielefeld, P., Fitzsimons, C. P., de Vries, H. E. & Schouten, M., 1 Aug 2018, In : Aging Cell. 17, 4, e12790

64. Using the glycan toolbox for pathogenic interventions and glycan immunotherapy. Li, R. E., van Vliet, S. J. & van Kooyk, Y., 1 Jun 2018, In : Current opinion in biotechnology. 51, p. 24-31 8 p.

65. Early intervention by Captopril does not improve wound healing of partial thickness burn wounds in a rat model. Akershoek, J. J. J., Brouwer, K. M., Vlig, M., Boekema, B. K. H. L., Beelen, R. H. J., Middelkoop, E. & Ulrich, M. M. W., 1 Mar 2018, In : Burns. 44, 2, p. 429-435 7 p.

66. Notch signaling is impaired during inflammation in a Lunatic Fringe-dependent manner. Derada Troletti, C., Lopes Pinheiro, M. A., Charabati, M., Gowing, E., van het Hof, B., van der Pol, S. M. A., Geerts, D., Prat, A., Fontijn, R. D., Unger, W. W. & de Vries, H. E., 1 Mar 2018, In : Brain, Behavior, and Immunity. 69, p. 48-56 9 p.

67. Disruption of sialic acid metabolism drives tumor growth by augmenting CD8+ T cell apoptosis. Cornelissen, L. A. M., Blanas, A., van der Horst, J. C., Kruijssen, L., Zaal, A., O'Toole, T., Wiercx, L., van Kooyk, Y. & van Vliet, S. J., 22 Dec 2018, In : International Journal of Cancer.

68. Macrophage CD40-signaling drives experimental autoimmune encephalomyelitis. Aarts, S. A. B. M., Seijkens, T. T. P., Kusters, P. J. H., van Tiel, C. M., Reiche, M. E., den Toom, M., Beckers, L., van Roomen, C. P. A. A., de Winther, M. P. J., Kooij, G. & Lutgens, E., 24 Nov 2018, In : Journal of Pathology.

69. Hypomorphic caspase activation and recruitment domain 11 (CARD11) mutations associated with diverse immunologic phenotypes with or without atopic disease

70. Dorjbal, B., Stinson, J. R., Ma, C. A., Weinreich, M. A., Miraghazadeh, B., Hartberger, J. M., Frey-Jakobs, S., Weidinger, S., Moebus, L., Franke, A., Schäffer, A. A., Bulashevska, A., Fuchs, S., Ehl, S., Limaye, S., Arkwright, P. D., Briggs, T. A., Langley, C., Bethune, C., Whyte, A. F. & 35 othersAlachkar, H., Nejentsev, S., DiMaggio, T., Nelson, C. G., Stone, K. D., Nason, M., Brittain, E. H., Oler, A. J., Veltri, D. P., Leahy, T. R., Conlon, N., Poli, M. C., Borzutzky, A., Cohen, J. I., Davis, J., Lambert, M. P., Romberg, N., Sullivan, K. E., Paris, K., Freeman, A. F., Lucas, L., Chandrakasan, S., Savic, S., Hambleton, S., Patel, S. Y., Jordan, M. B., Theos, A., Lebensburger, J., Atkinson, T. P., Torgerson, T. R., Chinn, I. K., Milner, J. D., Grimbacher, B., Cook, M. C. & Snow, A. L., 28 Aug 2018, In : Journal of Allergy and Clinical Immunology.

71. Progress on Reconstructed Human Skin Models for Allergy Research and Identifying Contact Sensitizers. Rodrigues Neves, C. & Gibbs, S., 23 Jun 2018, In : Current Topics in Microbiology and Immunology.

72. Novel IL2RG Mutation Causes Leaky TLOWB+NK+ SCID With Nodular Regenerative Hyperplasia and Normal IL-15 STAT5 Phosphorylation. Neves, J. F., Martins, C., Cordeiro, A. I., Neves, C., Plagnol, V., Curtis, J., Fabre, M., Bibi, S., Borrego, L. M., Moshous, D., Nejentsev, S. & Gilmour, K., 22 Jun 2018, In : Journal of Pediatric Hematology / Oncology.

73. A comprehensive proteomics study on platelet concentrates: Platelet proteome, storage time and Mirasol pathogen reduction technology. Salunkhe, V., De Cuyper, I. M., Papadopoulos, P., van der Meer, P. F., Daal, B. B., Villa-Fajardo, M., de Korte, D., van den Berg, T. K. & Gutiérrez, L., 19 Mar 2018, In : Platelets. p. 1-12 12 p.