Publications 2016

1. den Hoedt S, Janssen CI, Astarita G, Piomelli D, Leijten FP, Crivelli SM,Verhoeven AJ, de Vries HE, Walter J, Martinez-Martinez P, Sijbrands EJ, KiliaanAJ, Mulder MT. Pleiotropic Effect of Human ApoE4 on Cerebral Ceramide anSaturated Fatty Acid Levels. J Alzheimers Dis. 2016 Dec 30. doi:10.3233/JAD-160739. [Epub ahead of print] PubMed PMID: 28035926.

2. García-Santisteban I, Arregi I, Alonso-Mariño M, Urbaneja MA, Garcia-VallejoJJ, Bañuelos S, Rodríguez JA. A cellular reporter to evaluate CRM1 nuclear exportactivity: functional analysis of the cancer-related mutant E571K. Cell Mol LifeSci. 2016 Dec;73(24):4685-4699. PubMed PMID: 27312238.

3. Fraussen J, Claes N, Van Wijmeersch B, van Horssen J, Stinissen P, Hupperts R, Somers V. B cells of multiple sclerosis patients induce autoreactive
proinflammatory T cell responses. Clin Immunol. 2016 Dec;173:124-132. doi:10.1016/j.clim.2016.10.001. PubMed PMID: 27717695.

4. Bar-Ephraim YE, Konijn T, Gönültas M, Mebius RE, Reijmers RM. A Reproducible Method for Isolation and In Vitro Culture of Functional Human Lymphoid Stromal Cells from Tonsils. PLoS One. 2016 Dec 1;11(12):e0167555. doi:10.1371/journal.pone.0167555. PubMed PMID: 27907202; PubMed Central PMCID:PMC5132289.5
  
5. Aleyd E, Al M, Tuk CW, van der Laken CJ, van Egmond M. IgA Complexes in Plasmaand Synovial Fluid of Patients with Rheumatoid Arthritis Induce NeutrophilExtracellular Traps via Fc?RI. J Immunol. 2016 Dec 15;197(12):4552-4559. PubMedPMID: 27913645.

6. Walraven M, Akershoek JJ, Beelen RH, Ulrich MM. In vitro cultured fetal fibroblasts have myofibroblast-associated characteristics and produce a fibrotic-like environment upon stimulation with TGF-?1: Is there a thin line between fetal scarless healing and fibrosis? Arch Dermatol Res. 2016 Dec 21. doi:10.1007/s00403-016-1710-3. [Epub ahead of print] PubMed PMID: 28004279.

7. Liappas G, González-Mateo GT, Sánchez-Díaz R, Lazcano JJ, Lasarte S, Matesanz-Marín A, Zur R, Ferrantelli E, Ramírez LG, Aguilera A, Fernández-Ruiz E, Beelen RH, Selgas R, Sánchez-Madrid F, Martín P, López-Cabrera M. Immune-Regulatory Molecule CD69 Controls Peritoneal Fibrosis. J Am Soc Nephrol.2016 Dec;27(12):3561-3576. PubMed PMID: 27151919; PubMed Central PMCID: PMC5118477.

8. Hiemstra IH, van Hamme JL, Janssen MH, van den Berg TK, Kuijpers TW. Dexamethasone promotes granulocyte mobilization by prolonging the half-life of granulocyte-colony-stimulating factor in healthy donors for granulocyte
transfusions. Transfusion. 2016 Dec 28. doi: 10.1111/trf.13941. [Epub ahead of print] PubMed PMID: 28032635.

9. Kuijpers TW, Tool AT, van der Bijl I, de Boer M, van Houdt M, de Cuyper IM, Roos D, van Alphen F, van Leeuwen K, Cambridge EL, Arends MJ, Dougan G, Clare S, Ramirez-Solis R, Pals ST, Adams DJ, Meijer AB, van den Berg TK. Combined immunodeficiency with severe inflammation and allergy caused by ARPC1B deficiency. J Allergy Clin Immunol. 2016 Dec 10. pii: S0091-6749(16)31453-1. doi: 10.1016/j.jaci.2016.09.061. [Epub ahead of print] PubMed PMID: 27965109.

10. Scheenstra MR, De Cuyper IM, Branco-Madeira F, de Bleser P, Kool M, Meinders M, Hoogenboezem M, Mul E, Wolkers MC, Salerno F, Nota B, Saeys Y, Klarenbeek S, van IJcken WF, Hammad H, Philipsen S, van den Berg TK, Kuijpers TW, Lambrecht BN, Gutiérrez L. GATA1-Deficient Dendritic Cells Display Impaired CCL21-Dependent Migration toward Lymph Nodes Due to Reduced Levels of Polysialic Acid. J Immunol. 2016 Dec 1;197(11):4312-4324. PubMed PMID: 27815426.

11. Faraco G, Sugiyama Y, Lane D, Garcia-Bonilla L, Chang H, Santisteban MM, Racchumi G, Murphy M, Van Rooijen N, Anrather J, Iadecola C. Perivascular macrophages mediate the neurovascular and cognitive dysfunction associated with hypertension. J Clin Invest. 2016 Dec 1;126(12):4674-4689. doi: 10.1172/JCI86950. PMID:27841763

12. Matlung HL, Szilagyi K, Kuijpers TW, van Lier RA, van den Berg TK. Immune checkpoint blockade: Which switches to hit and how much? Immunol Lett. 2016 Dec;180:73-74. doi: 10.1016/j.imlet.2016.08.014. PubMed PMID: 27662791.

13. Ilarregui JM, van Beelen AJ, Fehres CM, Bruijns SC, García-Vallejo JJ, van Kooyk Y. New roles for CD14 and IL-? linking inflammatory dendritic cells to IL-17 production in memory CD4(+) T cells. Immunol Cell Biol. 2016
Nov;94(10):907-916. doi: 10.1038/icb.2016.66. PubMed PMID: 27550748.

14.  Menzel L, Paterka M, Bittner S, White R, Bobkiewicz W, van Horssen J, Schachner M, Witsch E, Kuhlmann T, Zipp F, Schäfer MK. Down-regulation of neuronal L1 cell adhesion molecule expression alleviates inflammatory neuronal injury. Acta Neuropathol. 2016 Nov;132(5):703-720. PubMed PMID: 27544757.

15. Chakraborty A, de Wit NM, van der Flier WM, de Vries HE. The blood brain barrier in Alzheimer's disease. Vascul Pharmacol. 2016 Nov 25. pii:S1537-1891(16)30252-X. doi: 10.1016/j.vph.2016.11.008. [Epub ahead of print] Review. PubMed PMID: 27894893.
 
16. Hollander MR, de Waard GA, Konijnenberg LS, Meijer-van Putten RM, van den Brom CE, Paauw N, de Vries HE, van de Ven PM, Aman J, Van Nieuw Amerongen GP, Hordijk PL, Niessen HW, Horrevoets AJ, Van Royen N. Correction: Dissecting the Effects of Ischemia and Reperfusion on the Coronary Microcirculation in a Rat Model of Acute Myocardial Infarction. PLoS One. 2016 Nov 15;11(11):e0166809. doi:10.1371/journal.pone.0166809. PubMed PMID: 27846269; PubMed Central PMCID:PMC5112929.

17. Attia S, Versloot CJ, Voskuijl W, van Vliet SJ, Di Giovanni V, Zhang L, Richardson S, Bourdon C, Netea MG, Berkley JA, van Rheenen PF, Bandsma RH. Mortality in children with complicated severe acute malnutrition is related to intestinal and systemic inflammation: an observational cohort study. Am J Clin Nutr. 2016 Nov;104(5):1441-1449. PubMed PMID: 27655441; PubMed Central PMCID: PMC5081715.

18. Butzelaar L, Schooneman DP, Soykan EA, Talhout W, Ulrich MM, van den Broek LJ, Gibbs S, Beelen RH, Mink van der Molen AB, Niessen FB. Inhibited early immunologic response is associated with hypertrophic scarring. Exp Dermatol. 2016 Oct;25(10):797-804. doi: 10.1111/exd.13100. PubMed PMID: 27249786.

19. Olivier BJ, Cailotto C, van der Vliet J, Knippenberg M, Greuter MJ, Hilbers FW, Konijn T, Te Velde AA, Nolte MA, Boeckxstaens GE, de Jonge WJ, Mebius RE. Vagal innervation is required for the formation of tertiary lymphoid tissue in colitis. Eur J Immunol. 2016 Oct;46(10):2467-2480. doi: 10.1002/eji.201646370. PubMed PMID: 27457277.

20. Gidwani K, Huhtinen K, Kekki H, van Vliet S, Hynninen J, Koivuviita N, Perheentupa A, Poutanen M, Auranen A, Grenman S, Lamminmäki U, Carpen O, van Kooyk Y, Pettersson K. A Nanoparticle-Lectin Immunoassay Improves Discrimination of Serum CA125 from Malignant and Benign Sources. Clin Chem. 2016 Oct;62(10):1390-400. doi: 10.1373/clinchem.2016.257691. PubMed PMID: 27540033.

21. Koning JJ, Konijn T, Lakeman KA, O'Toole T, Kenswil KJ, Raaijmakers MH, Michurina TV, Enikolopov G, Mebius RE. Nestin-Expressing Precursors Give Rise to Both Endothelial as well as Nonendothelial Lymph Node Stromal Cells. J Immunol. 2016 Oct 1;197(7):2686-94. doi: 10.4049/jimmunol.1501162. PubMed PMID: 27574301.
 
22. de Wit NM, Snkhchyan H, den Hoedt S, Wattimena D, de Vos R, Mulder MT, Walter J, Martinez-Martinez P, Hoozemans JJ, Rozemuller AJ, de Vries HE. Altered Sphingolipid Balance in Capillary Cerebral Amyloid Angiopathy. J Alzheimers Dis. 2016 Sep 21. [Epub ahead of print] PubMed PMID: 27662305.

23. de Wit NM, Vanmol J, Kamermans A, Hendriks J, de Vries HE. Inflammation at the blood-brain barrier: The role of liver X receptors. Neurobiol Dis. 2016 Sep 20. pii: S0969-9961(16)30231-5. doi: 10.1016/j.nbd.2016.09.015. [Epub ahead of print] Review. PubMed PMID: 27659108.

24. Lim JL, van der Pol SM, Baron W, McCord JM, de Vries HE, van Horssen J. Protandim Protects Oligodendrocytes against an Oxidative Insult. Antioxidants (Basel). 2016 Sep 7;5(3). pii: E30. doi: 10.3390/antiox5030030. PubMed PMID:27618111; PubMed Central PMCID: PMC5039579.

25. Treffers LW, Hiemstra IH, Kuijpers TW, van den Berg TK, Matlung HL. Neutrophils in cancer. Immunol Rev. 2016 Sep;273(1):312-28. doi:10.1111/imr.12444. Review. PubMed PMID: 27558343.

26. Gazendam RP, van de Geer A, Roos D, van den Berg TK, Kuijpers TW. How neutrophils kill fungi. Immunol Rev. 2016 Sep;273(1):299-311. doi:10.1111/imr.12454. Review. PubMed PMID: 27558342.

27. Gazendam RP, van de Geer A, van Hamme JL, Helgers L, Rohr J, Chrabieh M, Picard C, Roos D, van den Berg JM, van den Berg TK, Kuijpers TW. Proinflammatory cytokine response toward fungi but not bacteria in chronic granulomatous disease. J Allergy Clin Immunol. 2016 Sep;138(3):928-930.e4. doi:10.1016/j.jaci.2016.03.035. PubMed PMID: 27283382.

28. Macrez R, Ortega MC, Bardou I, Mehra A, Fournier A, Van der Pol SM, Haelewyn, Maubert E, Lesept F, Chevilley A, de Castro F, De Vries HE, Vivien D, Clemente , Docagne F. Neuroendothelial NMDA receptors as therapeutic targets in xperimental autoimmune encephalomyelitis. Brain. 2016 Sep;139(Pt 9):2406-19.doi: 10.1093/brain/aww172. PubMed PMID: 27435092.

29. Bambakidis T, Dekker SE, Sillesen M, Liu B, Johnson CN, Jin G, de Vries HE, Li Y, Alam HB. Resuscitation with Valproic Acid Alters Inflammatory Genes in a Porcine Model of Combined Traumatic Brain Injury and Hemorrhagic Shock. J Neurotrauma. 2016 Aug 15;33(16):1514-21. doi: 10.1089/neu.2015.4163. PubMed PMID:26905959.

30. Hoeksema MA, Laan LC, Postma JJ, Cummings RD, de Winther MP, Dijkstra CD, van Die I, Kooij G. Treatment with Trichuris suis soluble products during monocyte-to-macrophage differentiation reduces inflammatory responses through epigenetic remodeling. FASEB J. 2016 Aug;30(8):2826-36. doi:10.1096/fj.201600343R. PubMed PMID: 27095802.
 
31. Barateiro A, Afonso V, Santos G, Cerqueira JJ, Brites D, van Horssen J, Fernandes A. S100B as a Potential Biomarker and Therapeutic Target in Multiple Sclerosis. Mol Neurobiol. 2016 Aug;53(6):3976-91. doi: 10.1007/s12035-015-9336-6.PubMed PMID: 26184632.

32. Lopez-Ramirez MA, Reijerkerk A, de Vries HE, Romero IA. Regulation of brain endothelial barrier function by microRNAs in health and neuroinflammation. FASEB J. 2016 Aug;30(8):2662-72. doi: 10.1096/fj.201600435RR. Review. PubMed PMID:27118674.

33. van Leeuwen MA, Costes LM, van Berkel LA, Simons-Oosterhuis Y, du Pré MF, Kozijn AE, Raatgeep HC, Lindenbergh-Kortleve DJ, van Rooijen N, Koning F, Samsom JN. Macrophage-mediated gliadin degradation and concomitant IL-27 production drive IL-10- and IFN-?-secreting Tr1-like-cell differentiation in a murine model for gluten tolerance. Mucosal Immunol. 2016 Aug 31. doi: 10.1038/mi.2016.76. [Epub ahead of print: PMID: 27579860

34. Gillis CM, Jönsson F, Mancardi DA, Tu N, Beutier H, Van Rooijen N, Macdonald LE, Murphy AJ, Bruhns P. Mechanisms of anaphylaxis in human low-affinity IgG receptor locus knock-in mice. J Allergy Clin Immunol. 2016 Aug 24. pii: S0091-6749(16)30852-1. doi: 10.1016/j.jaci.2016.06.058. PMID: 2756808

35. Jansen MF, Hollander MR, van Royen N, Horrevoets AJ, Lutgens E. CD40 in coronary artery disease: a matter of macrophages? Basic Res Cardiol. 2016 Jul;111(4):38. doi: 10.1007/s00395-016-0554-5. Review. PubMed PMID: 27146510;PubMed Central PMCID: PMC4856717.

36. Duinkerken S, van Kooyk Y, Garcia-Vallejo JJ. Human cytomegalovirus-based immunotherapy to treat glioblastoma: Into the future. Oncoimmunology. 2016 Jul 25;5(9):e1214791. PubMed PMID: 27757314; PubMed Central PMCID: PMC5048761.

37. Silva M, Silva Z, Marques G, Ferro T, Gonçalves M, Monteiro M, van Vliet SJ, Mohr E, Lino AC, Fernandes AR, Lima FA, van Kooyk Y, Matos T, Tadokoro CE, Videira PA. Sialic acid removal from dendritic cells improves antigen cross-presentation and boosts anti-tumor immune responses. Oncotarget. 2016 Jul 5;7(27):41053-41066. doi: 10.18632/oncotarget.9419. PubMed PMID: 27203391; PubMed Central PMCID: PMC5173042.

38. van Horssen J, van der Pol S, Nijland P, Amor S, Perron H. Human endogenous retrovirus W in brain lesions: Rationale for targeted therapy in multiple sclerosis. Mult Scler Relat Disord. 2016 Jul;8:11-8. doi:10.1016/j.msard.2016.04.006. PubMed PMID: 27456869.

39. Tan J, McKenzie C, Vuillermin PJ, Goverse G, Vinuesa CG, Mebius RE, Macia L, Mackay CR. Dietary Fiber and Bacterial SCFA Enhance Oral Tolerance and Protect against Food Allergy through Diverse Cellular Pathways. Cell Rep. 2016 Jun 21;15(12):2809-24. doi: 10.1016/j.celrep.2016.05.047. PubMed PMID: 27332875.

40. Goverse G, Labao-Almeida C, Ferreira M, Molenaar R, Wahlen S, Konijn T, Koning J, Veiga-Fernandes H, Mebius RE. Vitamin A Controls the Presence of ROR γ+ Innate Lymphoid Cells and Lymphoid Tissue in the Small Intestine. J Immunol. 2016 Jun 15;196(12):5148-55. doi: 10.4049/jimmunol.1501106. PubMed PMID: 27183576.

41. Lopes Pinheiro MA, Kamermans A, Garcia-Vallejo JJ, van Het Hof B, Wierts L, O'Toole T, Boeve D, Verstege M, van der Pol SM, van Kooyk Y, de Vries HE, Unger WW. Internalization and presentation of myelin antigens by the brain endothelium guides antigen-specific T cell migration. Elife. 2016 Jun 23;5. pii: e13149. doi:10.7554/eLife.13149. PubMed PMID: 27336724; PubMed Central PMCID: PMC4959842.

42. Ates LS, van der Woude AD, Bestebroer J, van Stempvoort G, Musters RJ, Garcia-Vallejo JJ, Picavet DI, Weerd Rv, Maletta M, Kuijl CP, van der Wel NN, Bitter W. The ESX-5 System of Pathogenic Mycobacteria Is Involved In Capsule Integrity and Virulence through Its Substrate PPE10. PLoS Pathog. 2016 Jun 9;12(6):e1005696. doi: 10.1371/journal.ppat.1005696. PubMed PMID: 27280885;PubMed Central PMCID: PMC4900558.

43. Szulcek R, Happé CM, Rol N, Fontijn RD, Dickhoff C, Hartemink KJ, Grünberg K, Tu L, Timens W, Nossent GD, Paul MA, Leyen TA, Horrevoets AJ, de Man FS, Guignabert C, Yu PB, Vonk-Noordegraaf A, van Nieuw Amerongen GP, Bogaard HJ. Delayed Microvascular Shear Adaptation in Pulmonary Arterial Hypertension. Role of Platelet Endothelial Cell Adhesion Molecule-1 Cleavage. Am J Respir Crit Care Med. 2016 Jun 15;193(12):1410-20. doi: 10.1164/rccm.201506-1231OC. PubMed PMID:26760925.

44. Walraven M, van Vliet SJ, Beelen RH, van Egmond M, Ulrich MM. Blocking α1-integrin reverts the adhesive phenotype of adult fibroblasts towards a
foetal-like migratory phenotype. Exp Dermatol. 2016 Jun;25(6):480-2. doi:10.1111/exd.12977. PubMed PMID: 27294728.

45. Schenk GJ, de Vries HE. Altered blood-brain barrier transport in neuro-inflammatory disorders. Drug Discov Today Technol. 2016 Jun;20:5-11. doi:10.1016/j.ddtec.2016.07.002. Review. PubMed PMID: 27986224.

46. van der Hoeven NW, Hollander MR, Yildirim C, Jansen MF, Teunissen PF, Horrevoets AJ, van der Pouw Kraan TC, van Royen N. The emerging role of galectins in cardiovascular disease. Vascul Pharmacol. 2016 Jun;81:31-41. doi:10.1016/j.vph.2016.02.006. Review. PubMed PMID: 26945624.

47. Lim JL, van der Pol SM, Di Dio F, van Het Hof B, Kooij G, de Vries HE, van Horssen J. Protective effects of monomethyl fumarate at the inflamed blood-brain barrier. Microvasc Res. 2016 May;105:61-9. doi:10.1016/j.mvr.2015.12.003. PubMedPMID: 26679389.

48. Carvalho AN, Marques C, Guedes RC, Castro-Caldas M, Rodrigues E, van Horssen J, Gama MJ. S-Glutathionylation of Keap1: a new role for glutathione S-transferase pi in neuronal protection. FEBS Lett. 2016 May;590(10):1455-66. doi: 10.1002/1873-3468.12177. PubMed PMID: 27086966.

49. Cornelissen LA, Van Vliet SJ. A Bitter Sweet Symphony: Immune Responses to Altered O-glycan Epitopes in Cancer. Biomolecules. 2016 May 3;6(2). pii: E26. doi: 10.3390/biom6020026. Review. PubMed PMID: 27153100; PubMed Central PMCID:PMC4919921.

50. Walraven M, Talhout W, Beelen RH, van Egmond M, Ulrich MM. Healthy human second-trimester fetal skin is deficient in leukocytes and associated homing chemokines. Wound Repair Regen. 2016 May;24(3):533-41. doi: 10.1111/wrr.12421.PubMed PMID: 26873861.

51. Bar-Ephraïm YE, Mebius RE. Innate lymphoid cells in secondary lymphoid organs. Immunol Rev. 2016 May;271(1):185-99. doi: 10.1111/imr.12407. Review. PubMed PMID:27088915.

52. Meinders M, Hoogenboezem M, Scheenstra MR, De Cuyper IM, Papadopoulos P, Németh T, Mócsai A, van den Berg TK, Kuijpers TW, Gutiérrez L. Repercussion of Megakaryocyte-Specific Gata1 Loss on Megakaryopoiesis and the Hematopoietic Precursor Compartment. PLoS One. 2016 May 6;11(5):e0154342. doi:10.1371/journal.pone.0154342. PubMed PMID: 27152938; PubMed Central PMCID:PMC4859556.

53. Gazendam RP, van de Geer A, van Hamme JL, Tool AT, van Rees DJ, Aarts CE, van den Bmechaniselaar M, van Alphen F, Verkuijlen P, Meijer AB, Janssen H, Roos D, van den Berg TK, Kuijpers TW. Impaired killing of Candida albicans by granulocytes mobilized for transfusion purposes: a role for granule components. Haematologica. 2016 May;101(5):587-96. doi: 10.3324/haematol.2015.136630. PubMed PMID: 26802050; PubMed Central PMCID: PMC5004374.

54. Akershoek JJ, Vlig M, Talhout W, Boekema BK, Richters CD, Beelen RH, Brouwer KM, Middelkoop E, Ulrich MM. Cell therapy for full-thickness wounds: are fetal dermal cells a potential source? Cell Tissue Res. 2016 Apr;364(1):83-94. doi:10.1007/s00441-015-2293-6. PubMed PMID: 26453400; PubMed Central PMCID:PMC4819738.

55. Carvalho AN, Firuzi O, Gama MJ, van Horssen J, Saso L. Oxidative stress and antioxidants in neurological diseases: is there still hope? Curr Drug Targets. 2016 Apr 1. [Epub ahead of print] PubMed PMID: 27033198.

56. van Rees DJ, Szilagyi K, Kuijpers TW, Matlung HL, van den Berg TK. Immunoreceptors on neutrophils. Semin Immunol. 2016 Apr;28(2):94-108. doi:10.1016/j.smim.2016.02.004. Review. PubMed PMID: 26976825.

57. Vries HE, Schwaninger M. Neuroinflammation: A common denominator for stroke, multiple sclerosis and Alzheimer's disease. Biochim Biophys Acta. 2016 Mar;1862(3):297-8. doi: 10.1016/j.bbadis.2015.12.024. PubMed PMID: 26748252.

58. Ferrantelli E, Liappas G, Vila Cuenca M, Keuning ED, Foster TL, Vervloet MG, Lopéz-Cabrera M, Beelen RH. The dipeptide alanyl-glutamine ameliorates peritoneal fibrosis and attenuates IL-17 dependent pathways during peritoneal dialysis. Kidney Int. 2016 Mar;89(3):625-35. doi: 10.1016/j.kint.2015.12.005. PubMed PMID:26880457.

59. Lopes Pinheiro MA, Kooij G, Mizee MR, Kamermans A, Enzmann G, Lyck R, Schwaninger M, Engelhardt B, de Vries HE. Immune cell trafficking across the barriers of the central nervous system in multiple sclerosis and stroke. Biochim Biophys Acta. 2016 Mar;1862(3):461-71. doi: 10.1016/j.bbadis.2015.10.018. Review.PubMed PMID: 26527183.

60. Smit B, Smulders YM, de Waard MC, Boer C, Vonk AB, Veerhoek D, Kamminga S, de Grooth HJ, García-Vallejo JJ, Musters RJ, Girbes AR, Oudemans-van Straaten HM, Spoelstra-de Man AM. Moderate hyperoxic versus near-physiological oxygen targets during and after coronary artery bypass surgery: a randomised controlled trial. Crit Care. 2016 Mar 10;20:55. doi: 10.1186/s13054-016-1240-6. PubMed PMID:26968380; PubMed Central PMCID: PMC4788916.

61. Perdicchio M, Ilarregui JM, Verstege MI, Cornelissen LA, Schetters ST, Engels S, Ambrosini M, Kalay H, Veninga H, den Haan JM, van Berkel LA, Samsom JN, Crocker PR, Sparwasser T, Berod L, Garcia-Vallejo JJ, van Kooyk Y, Unger WW. Sialic acid-modified antigens impose tolerance via inhibition of T-cell proliferation and de novo induction of regulatory T cells. Proc Natl Acad Sci U S 2016 Mar 22;113(12):3329-34. doi:10.1073/pnas.1507706113. PubMed PMID:26941238; PubMed Central PMCID: PMC4812702.

62. Streng-Ouwehand I, Ho NI, Litjens M, Kalay H, Boks MA, Cornelissen LA, Kaur Singh S, Saeland E, Garcia-Vallejo JJ, Ossendorp FA, Unger WW, van Kooyk Y. Glycan modification of antigen alters its intracellular routing in dendritic cells, promoting priming of T cells. Elife. 2016 Mar 21;5. pii: e11765. doi:10.7554/eLife.11765. PubMed PMID: 26999763; PubMed Central PMCID: PMC4811763.

63. Troletti CD, de Goede P, Kamermans A, de Vries HE. Molecular alterations of the blood-brain barrier under inflammatory conditions: The role of endothelial to mesenchymal transition. Biochim Biophys Acta. 2016 Mar;1862(3):452-60. doi:10.1016/j.bbadis.2015.10.010. PubMed PMID: 26493443.

64. Lassmann H, van Horssen J. Oxidative stress and its impact on neurons and glia in multiple sclerosis lesions. Biochim Biophys Acta. 2016 Mar;1862(3):506-10.doi: 10.1016/j.bbadis.2015.09.018. PubMed PMID: 26432481.

65. de Wit NM, Kooij G, de Vries HE. In Vitro and Ex Vivo Model Systems to Measure ABC Transporter Activity at the Blood-Brain Barrier. Curr Pharm Des. 2016;22(38):5768-5773. PubMed PMID: 27514708.

66. Butzelaar L, Ulrich MM, Mink van der Molen AB, Niessen FB, Beelen RH. Currently known risk factors for hypertrophic skin scarring: A review. J Plast Reconstr Aesthet Surg. 2016 Feb;69(2):163-9. doi:10.1016/j.bjps.2015.11.015. Review. PubMed PMID: 26776348.

67. Perdicchio M, Cornelissen LA, Streng-Ouwehand I, Engels S, Verstege MI, Boon L, Geerts D, van Kooyk Y, Unger WW. Tumor sialylation impedes T cell mediated anti-tumor responses while promoting tumor associated-regulatory T cells. Oncotarget. 2016 Feb 23;7(8):8771-82. doi: 10.18632/oncotarget.6822. PubMed PMID:26741508; PubMed Central PMCID: PMC4891003.

68. Galletti G, Scielzo C, Barbaglio F, Rodriguez TV, Riba M, Lazarevic D, Cittaro D, Simonetti G, Ranghetti P, Scarfò L, Ponzoni M, Rocchi M, Corti A, Anselmo A, van Rooijen N, Klein C, Ries CH, Ghia P, De Palma M, Caligaris-Cappio F, Bertilaccio MT. Targeting Macrophages Sensitizes Chronic Lymphocytic Leukemia to Apoptosis and Inhibits Disease Progression. Cell Rep. 2016 Feb 23;14(7):1748-60. doi:10.1016/j.celrep.2016.01.042.PMID:26876171

69. Ngoh EN, Weisser SB, Lo Y, Kozicky LK, Jen R, Brugger HK, Menzies SC, McLarren KW, Nackiewicz D, van Rooijen N, Jacobson K, Ehses JA, Turvey SE, Sly LM. Activity of SHIP, Which Prevents Expression of Interleukin 1 β, Is Reduced in Patients With Crohn's Disease. Gastroenterology. 2016 Feb;150(2):465-76. doi: 10.1053/j.gastro.2015.09.049. PMID: 26481854

70. Koning JJ, Mebius RE. Fungi Take Control of Lymphocyte Recirculation. Immunity. 2016 Feb 16;44(2):211-3. doi: 10.1016/j.immuni.2016.01.017. PubMed PMID: 26885851.

71. de Jong TD, Vosslamber S, Mantel E, de Ridder S, Wesseling JG, van der Pouw Kraan TC, Leurs C, Hegen H, Deisenhammer F, Killestein J, Lundberg IE, Vencovsky J, Nurmohamed MT, van Schaardenburg D, Bultink IE, Voskuyl AE, Pegtel DM, van der Laken CJ, Bijlsma JW, Verweij CL. Physiological evidence for diversification of IFN α and IFN β-mediated response programs in different autoimmune diseases.
Arthritis Res Ther. 2016 Feb 17;18:49. doi: 10.1186/s13075-016-0946-9. PubMed PMID: 26882897; PubMed Central PMCID: PMC4756531.

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